From the Masspike (I 90)

Take Masspike Eastbound to the Prudential Exit and stay right for Copley Place. Continue on Stuart Street and take left on Charles Street South, which will turn into Charles Street after the first traffic light. Enter the garage via the Charles Street entrance ramp. 

From the Southeast Expressway (I 93/RT. 3 North)

Take exit 20 toward I-90, Airport & South Station. Then, take a left toward South Station. At the light Turn left (West) onto Kneeland St. Kneeland Street becomes  Stuart Street From Stuart Street, take a Richt on Charles Street. Follow Charles Street for one block, then enter the garage via the ramp on your right. 
 

From 93 South

Take exit 26 toward Storrow Drive-North Station, then follow Storrow Drive heading westbound. Take the Backbay / Copley Square exit on your left. At the end of the exit, take a left. Then take your first right onto Arlington Street. At second light, take a left onto Boylston Street. At second light, take a left onto Charles Street. Enter the garage via the ramp on your right.
 

From Storrow Drive

If you're coming on Storrow Drive heading eastbound, take the Downtown / Boston exit. Turn left on Beacon street, then take your first right onto Arlington Street. Turn left onto Boylston Street, then take a slight left onto Charles Street. Enter the garage via the ramp on your right.